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CD46 and CD59 inhibitors enhance complement-dependent cytotoxicity of anti-CD38 monoclonal antibodies daratumumab and isatuximab in multiple myeloma and other B-cell malignancy cells

The intrinsic pathway is characterized by mitochondrial outer membrane permeabilization (MOMP), predominantly mediated by Bax/Bcl2-antagonist killer oligomerization, which forms pores in the outer mitochondrial membrane, promoting the cytoplasmic release of Cyt c and mtDNA (Riley et al., 2018

While free radicals themselves arent necessarily bad, the problem happens when your body produces more free radicals than your body has antioxidants to neutralize

This is in marked contrast to classic antioxidants which generally scavenge a single radical